Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506) | Zendy

Carlos Barreiro | Zendy; Carlos Alberto Vanegas Prieto | Zendy; Alberto SolaLanda | Zendy; Elena Solera | Zendy; Miriam Martínez-Castro | Zendy; Rosario PérezRedondo | Zendy; Carlos GarcíaEstrada | Zendy; Jesús F. Aparicio | Zendy; Lorena T. FernándezMartínez | Zendy; Javier SantosAberturas | Zendy; Zahra Salehi-Najafabadi | Zendy; Antonio RodríguezGarcía | Zendy; Andreas Tauch | Zendy; Juan F. Martı́n | Zendy

Open Access

Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506)

Author(s) -

Carlos Barreiro,

Carlos Alberto Vanegas Prieto,

Alberto SolaLanda,

Elena Solera,

Miriam Martínez-Castro,

Rosario PérezRedondo,

Carlos GarcíaEstrada,

Jesús F. Aparicio,

Lorena T. FernándezMartínez,

Javier SantosAberturas,

Zahra Salehi-Najafabadi,

Antonio RodríguezGarcía,

Andreas Tauch,

Juan F. Martı́n

Publication year - 2012

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.00692-12

Subject(s) - biology , tacrolimus , streptomyces , polyketide , whole genome sequencing , gene , gene cluster , genome , genetics , strain (injury) , streptomycetaceae , microbiology and biotechnology , biosynthesis , actinomycetales , bacteria , transplantation , anatomy , medicine , surgery

The macrocyclic polyketide tacrolimus (FK506) is a potent immunosuppressant that prevents T-cell proliferation produced solely by Streptomyces species. We report here the first draft genome sequence of a true FK506 producer, Streptomyces tsukubaensis NRRL 18488, the first tacrolimus-producing strain that was isolated and that contains the full tacrolimus biosynthesis gene cluster.

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