The Elemental Sulfur-Responsive Protein (SipA) from the Hyperthermophilic Archaeon Pyrococcus furiosus Is Regulated by Sulfide in an Iron-Dependent Manner | Zendy

Sonya M. Clarkson | Zendy; Elizabeth C. Newcomer | Zendy; Everett Young | Zendy; Michael W. W. Adams | Zendy

Open Access

The Elemental Sulfur-Responsive Protein (SipA) from the Hyperthermophilic Archaeon Pyrococcus furiosus Is Regulated by Sulfide in an Iron-Dependent Manner

Author(s) -

Sonya M. Clarkson,

Elizabeth C. Newcomer,

Everett Young,

Michael W. W. Adams

Publication year - 2010

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.00660-10

Subject(s) - pyrococcus furiosus , sulfur , sulfide , biology , biochemistry , rubredoxin , intracellular , gene , archaea , microbiology and biotechnology , biophysics , materials science , metallurgy

The gene (sipA ) encoding the sulfur-induced protein A (PF2025) is highly upregulated during growth ofPyrococcus furiosus on elemental sulfur (S0 ). Expression ofsipA is regulated by sulfide, the product of S0 reduction, but in an iron-dependent manner. SipA is proposed to play a role in intracellular iron sulfide detoxification.

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