Open AccessThe Elemental Sulfur-Responsive Protein (SipA) from the Hyperthermophilic Archaeon Pyrococcus furiosus Is Regulated by Sulfide in an Iron-Dependent Manner
Author(s) -
Sonya M. Clarkson,
Elizabeth C. Newcomer,
Everett Young,
Michael W. W. Adams
Publication year - 2010
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.00660-10
Subject(s) - pyrococcus furiosus , sulfur , sulfide , biology , biochemistry , rubredoxin , intracellular , gene , archaea , microbiology and biotechnology , biophysics , materials science , metallurgy
The gene (sipA ) encoding the sulfur-induced protein A (PF2025) is highly upregulated during growth ofPyrococcus furiosus on elemental sulfur (S0 ). Expression ofsipA is regulated by sulfide, the product of S0 reduction, but in an iron-dependent manner. SipA is proposed to play a role in intracellular iron sulfide detoxification.