Open AccessThe Escherichia coli CRISPR System Protects from λ Lysogenization, Lysogens, and Prophage Induction
Author(s) -
Rotem Edgar,
Udi Qimron
Publication year - 2010
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.00644-10
Subject(s) - lysogen , prophage , lysogenic cycle , biology , crispr , escherichia coli , genetics , sos response , temperateness , bacteriophage , microbiology and biotechnology , gene
We show that phage lysogenization, lysogens, and prophage induction are all targeted by CRISPR. The results demonstrate that genomic DNA is not immune to the CRISPR system, that the CRISPR system does not require noncytoplasmic elements, and that the system protects from phages entering and exiting the lysogenic cycle.
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