Regulation of Proteolysis in the Gram-Negative Bacterial Envelope | Zendy

Tracy Raivio | Zendy

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Regulation of Proteolysis in the Gram-Negative Bacterial Envelope

Author(s) -

Tracy Raivio

Publication year - 2017

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.00639-17

Subject(s) - biology , proteolysis , gram , gram negative bacteria , bacterial protein , microbiology and biotechnology , envelope (radar) , cell envelope , bacteria , biochemistry , genetics , escherichia coli , enzyme , gene , telecommunications , radar , computer science

Proteolysis is carefully regulated to prevent the untimely destruction of critical proteins. In this issue of the Journal of Bacteriology , Kim and colleagues identify YjfN as a proteolytic regulator that stimulates the activity of the DegP/HtrA protease of Escherichia coli (S. Kim, I. Song, G. Eom, and S. Kim, J Bacteriol 200:e00519-17, 2018, https://doi.org/10.1128/JB.00519-17). The suicide destruction and transcriptional regulation of YjfN limit its activity to conditions in which there are likely to be many misfolded substrate proteins present.

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