Bacillus subtilisTerC Family Proteins Help Prevent Manganese Intoxication | Zendy

Srinand Paruthiyil | Zendy; Azul PinochetBarros | Zendy; Xiaojuan Huang | Zendy; John D. Helmann | Zendy

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Bacillus subtilisTerC Family Proteins Help Prevent Manganese Intoxication

Author(s) -

Srinand Paruthiyil,

Azul PinochetBarros,

Xiaojuan Huang,

John D. Helmann

Publication year - 2019

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.00624-19

Subject(s) - biology , bacillus subtilis , repressor , activator (genetics) , gene , manganese , transcription factor , biochemistry , genetics , bacteria , microbiology and biotechnology , chemistry , organic chemistry

Manganese homeostasis is primarily regulated at the level of transport.Bacillus subtilis MntR serves as a Mn(II)-activated repressor of importer genes (mntH andmntABC ) and an activator of efflux genes (mneP andmneS ). Elevated intracellular Mn(II) also binds to Mn-sensing riboswitches to activate transcription ofyybP andykoY , which encodes a TerC family member. Here, we demonstrate that two TerC family proteins, YceF and YkoY, help prevent Mn(II) intoxication. TerC family proteins are widespread in bacteria and may influence host-pathogen interactions, but their effects on Mn(II) homeostasis are unclear. Our results suggest that TerC proteins work by Mn(II) export under Mn(II) overload conditions to help alleviate toxicity.

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