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Manganese homeostasis is primarily regulated at the level of transport.Bacillus subtilis MntR serves as a Mn(II)-activated repressor of importer genes (mntH andmntABC ) and an activator of efflux genes (mneP andmneS ). Elevated intracellular Mn(II) also binds to Mn-sensing riboswitches to activate transcription ofyybP andykoY , which encodes a TerC family member. Here, we demonstrate that two TerC family proteins, YceF and YkoY, help prevent Mn(II) intoxication. TerC family proteins are widespread in bacteria and may influence host-pathogen interactions, but their effects on Mn(II) homeostasis are unclear. Our results suggest that TerC proteins work by Mn(II) export under Mn(II) overload conditions to help alleviate toxicity.

Bacillus subtilisTerC Family Proteins Help Prevent Manganese Intoxication