Availability of Zinc Impacts Interactions between Streptococcus sanguinis and Pseudomonas aeruginosa in Coculture | Zendy

Kewei Li | Zendy; Alex H. Gifford | Zendy; Thomas H. Hampton | Zendy; George A. O’Toole | Zendy

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Availability of Zinc Impacts Interactions between Streptococcus sanguinis and Pseudomonas aeruginosa in Coculture

Author(s) -

Kewei Li,

Alex H. Gifford,

Thomas H. Hampton,

George A. O’Toole

Publication year - 2019

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.00618-19

Subject(s) - biology , streptococcus sanguinis , pseudomonas aeruginosa , microbiology and biotechnology , streptococcus , zinc , pseudomonadales , pseudomonadaceae , bacteria , streptococcus mutans , genetics , materials science , metallurgy

Polymicrobial infections in CF cases likely impact patient health, but the mechanism(s) underlying such interactions is poorly understood. Here, we show using anin vitro model system that interactions betweenPseudomonas andStreptococcus are modulated by zinc availability, and clinical data are consistent with this model. Together with previous studies, our work supports a role for metal homeostasis as a key factor driving microbial interactions.

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