Open AccessBacterial Homologs of Progestin and AdipoQ Receptors (PAQRs) Affect Membrane Energetics Homeostasis but Not Fluidity
Author(s) -
Maddison V Melchionna,
Jessica M. Gullett,
Emmanuelle Bouveret,
Him K. Shrestha,
Paul E. Abraham,
Robert L. Hettich,
Gladys Alexandre
Publication year - 2022
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.00583-21
Subject(s) - biology , receptor , homeostasis , energetics , membrane fluidity , microbiology and biotechnology , membrane , biochemistry , ecology
Eukaryotic homologs of the progestin and AdipoQ receptor family (PAQR) have been shown to regulate membrane fluidity by affecting, through unknown mechanisms, unsaturated fatty acid (FA) metabolism. The bacterial homologs studied here mediate small and consistent changes in unsaturated FA metabolism that do not seem to impact membrane fluidity but, rather, alter membrane energetics homeostasis.