Independent Control of Replication Initiation of the Two Vibrio cholerae Chromosomes by DnaA and RctB | Zendy

Stéphane Duigou | Zendy; K Knudsen | Zendy; Ole Skovgaard | Zendy; Elizabeth S. Egan | Zendy; Anders LøbnerOlesen | Zendy; Matthew K. Waldor | Zendy

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Independent Control of Replication Initiation of the Two Vibrio cholerae Chromosomes by DnaA and RctB

Author(s) -

Stéphane Duigou,

K Knudsen,

Ole Skovgaard,

Elizabeth S. Egan,

Anders LøbnerOlesen,

Matthew K. Waldor

Publication year - 2006

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.00565-06

Subject(s) - dnaa , biology , vibrio cholerae , chromosome , overproduction , genetics , dna replication , homologous chromosome , chromosome segregation , control of chromosome duplication , circular bacterial chromosome , origin of replication , origin recognition complex , microbiology and biotechnology , dna , eukaryotic dna replication , gene , bacteria

Although the two Vibrio cholerae chromosomes initiate replication in a coordinated fashion, we show here that each chromosome appears to have a specific replication initiator. DnaA overproduction promoted overinitiation of chromosome I and not chromosome II. In contrast, overproduction of RctB, a protein that binds to the origin of replication of chromosome II, promoted overinitiation of chromosome II and not chromosome I.

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