Open AccessQseA and GrlR/GrlA Regulation of the Locus of Enterocyte Effacement Genes in Enterohemorrhagic Escherichia coli
Author(s) -
Regan M. Russell,
Faith C. Sharp,
David A. Rasko,
Vanessa Sperandio
Publication year - 2007
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.00553-07
Subject(s) - biology , enterocyte , escherichia coli , gene , transcription (linguistics) , locus (genetics) , transcription factor , genetics , biochemistry , small intestine , linguistics , philosophy
Transcription of the locus of enterocyte effacement (LEE) genes in enterohemorrhagicEscherichia coli (EHEC) is regulated by the LEE-encoded Ler and GrlR/GrlA proteins as well as the non-LEE-encoded regulator QseA. This work demonstrates that GrlR/GrlA activateLEE2 transcription in a Ler-independent fashion, whereas transcription ofgrlRA is activated by QseA in both Ler-dependent and -independent manners.