Edwardsiella piscicida Enters Nonphagocytic Cells via a Macropinocytosis-Involved Hybrid Mechanism | Zendy

Tianjian Hu | Zendy; Lingzhi Zhang | Zendy; Wei Wang | Zendy; Dahai Yang | Zendy; Jingfan Xiao | Zendy; Yuanxing Zhang | Zendy; Xiaohong Liu | Zendy; Qin Liu | Zendy

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Edwardsiella piscicida Enters Nonphagocytic Cells via a Macropinocytosis-Involved Hybrid Mechanism

Author(s) -

Tianjian Hu,

Lingzhi Zhang,

Wei Wang,

Dahai Yang,

Jingfan Xiao,

Yuanxing Zhang,

Xiaohong Liu,

Qin Liu

Publication year - 2018

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.00548-18

Subject(s) - internalization , biology , pinocytosis , endocytosis , microbiology and biotechnology , phagosome , cell , phagocytosis , biochemistry

Bacterial internalization is the first step in breaking through the host cell defense. Therefore, studying the mechanism of bacterial internalization improves the understanding of the pathogenic mechanism of bacteria. In this study, the internalization process on nonphagocytic cells byEdwardsiella piscicida was evaluated. Our results showed thatE. piscicida can be internalized into nonphagocytic cells via macropinocytosis and caveolin-mediated endocytosis, and that cholesterol and dynamin are involved in this process. These results reveal a new method for inhibitingE. piscicida infection, providing a foundation for further studies of bacterial pathogenicity.

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