Open AccessGenetic Structure of the nadA and nadB Antivirulence Loci in Shigella spp
Author(s) -
AnneLaure Prunier,
Raymond Schuch,
Reinaldo E. Fernández,
Anthony T. Maurelli
Publication year - 2007
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.00525-07
Subject(s) - biology , shigella , escherichia coli , microbiology and biotechnology , shigella dysenteriae , auxotrophy , locus (genetics) , genetics , gene
Comparison of nadA and nadB in 14 Shigella strains and enteroinvasive Escherichia coli versus E. coli showed that at least one locus is altered in all strains. These observations explain the characteristic nicotinic acid auxotrophy of Shigella organisms and are consistent with the previously identified antivirulence nature of these genes for these pathogens.
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