Open AccessA Critical Process Controlled by MalT and OmpR Is Revealed through Synthetic Lethality
Author(s) -
Sylvia A. Reimann,
Alan J. Wolfe
Publication year - 2009
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.00522-09
Subject(s) - biology , porin , bacterial outer membrane , microbiology and biotechnology , programmed cell death , genetics , apoptosis , escherichia coli , gene
The death of cells harboring defects in two distinct pathways implicates these pathways in the control of an essential process. Here we report that cells lacking OmpR and harboring constitutively active MalT undergo premature death that involves increased expression of the outer membrane porin LamB.
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