Small RNAs Repress Expression of Polysaccharide Utilization Loci of Gut Bacteroides Species | Zendy

Laurie E. Comstock | Zendy

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Small RNAs Repress Expression of Polysaccharide Utilization Loci of Gut Bacteroides Species

Author(s) -

Laurie E. Comstock

Publication year - 2016

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.00514-16

Subject(s) - biology , glycan , bacteroides , bacteroides thetaiotaomicron , bacteriology , polysaccharide , gene , transfer rna , genetics , rna , microbiology and biotechnology , bacteria , biochemistry , glycoprotein

Bacteroides species can metabolize numerous plant polysaccharides and host glycans present in the mammalian gut. The regulatory systems governing the induction of particular polysaccharide utilization loci when the cognate glycan is present are known, but how expression is repressed when a higher-priority glycan is present is largely unknown. In this issue of the Journal of Bacteriology, Cao et al. (J. Bacteriol. 198:2410-2418, 2016, http://dx.doi.org/10.1128/JB.00381-16) reveal a conserved mechanism in Bacteroides whereby antisense small RNAs (sRNA) repress expression of genes involved in utilization of host glycans.

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