Open AccessfolA, a New Member of the TyrR Regulon inEscherichia coliK-12
Author(s) -
Ji Yang,
Yoshito Ogawa,
H Camakaris,
Tomohiro Shimada,
Akira Ishihama,
A J Pittard
Publication year - 2007
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.00482-07
Subject(s) - regulon , biology , genetics , gene , escherichia coli , rna polymerase , transcription factor , promoter , transcription (linguistics) , protein subunit , gene expression , linguistics , philosophy
The folA gene was identified as a new member of the TyrR regulon by genomic SELEX. Binding of TyrR to two sites in folA activated its transcription. Mutations in the N-terminal or central domain of TyrR, the alpha subunit of RNA polymerase, or integration host factor all abolished activation of the folA promoter.
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