Making and Breaking of an Essential Poison: the Cyclases and Phosphodiesterases That Produce and Degrade the Essential Second Messenger Cyclic di-AMP in Bacteria | Zendy

Fabian M. Commichau | Zendy; Jana L. Heidemann | Zendy; Ralf Ficner | Zendy; Jörg Stülke | Zendy

Open Access

Making and Breaking of an Essential Poison: the Cyclases and Phosphodiesterases That Produce and Degrade the Essential Second Messenger Cyclic di-AMP in Bacteria

Author(s) -

Fabian M. Commichau,

Jana L. Heidemann,

Ralf Ficner,

Jörg Stülke

Publication year - 2018

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.00462-18

Subject(s) - biology , phosphodiesterase , second messenger system , bacteria , biochemistry , bacterial protein , enzyme , microbiology and biotechnology , genetics

Cyclic di-AMP is a second-messenger nucleotide that is produced by many bacteria and some archaea. Recent work has shown that c-di-AMP is unique among the signaling nucleotides, as this molecule is in many bacteria both essential on one hand and toxic upon accumulation on the other.

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