Open AccessIdentification of a Polyprenylphosphomannosyl Synthase Involved in the Synthesis of Mycobacterial Mannosides
Author(s) -
Hataichanok Scherman,
Davinder Kaur,
Hà Phạm,
Henrieta Škovierová,
Mary Jackson,
Patrick J. Brennan
Publication year - 2009
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.00431-09
Subject(s) - lipoarabinomannan , biology , mycobacterium tuberculosis , glycosyltransferase , identification (biology) , microbiology and biotechnology , mycobacterium , epitope , atp synthase , tuberculosis , biochemistry , antigen , immunology , bacteria , enzyme , genetics , medicine , botany , pathology
We report on the identification of a glycosyltransferase (GT) fromMycobacterium tuberculosis H37Rv, Rv3779, of the membranous GT-C superfamily responsible for the direct synthesis of polyprenyl-phospho-mannopyranose and thus indirectly for lipoarabinomannan, lipomannan, and the higher-order phosphatidyl-myo -inositol mannosides.
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