Open AccessFeedback Regulation of Lac Repressor Expression inEscherichia coli
Author(s) -
Stefan Oehler
Publication year - 2009
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.00427-09
Subject(s) - lac repressor , repressor , biology , lac operon , autoregulation , escherichia coli , regulation of gene expression , yy1 , beta galactosidase , genetics , gene , gene expression , promoter , endocrinology , blood pressure
Negative feedback regulation, mediated through repressor binding site O3, which overlaps the lacI gene, could explain the robustness of the weak expression of Lac repressor. Significant autorepression of Lac repressor has never been ruled out. In the work presented here, the degree of autoregulation of Lac repressor was determined. It is negligible.
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