Learning from Adversity?

Many two-component regulatory systems, including Escherichia coli PhoRB, are positively autoregulated, so stimuli result in an increase in the concentration of signaling proteins. When the quantity of signaling proteins depends on exposure history, how do past conditions affect future responses to stimuli? Hoffer et al. (J. Bacteriol. 183:4914-4917, 2001, https://doi.org/doi:10.1128/JB.183.16.4914-4917.2001) previously reported that E. coli bacteria "learn" from phosphate starvation and respond more rapidly to subsequent episodes of starvation. Gao et al. (J. Bacteriol. 199:e00390-17, 2017, https://doi.org/doi:10.1128/JB.00390-17) describe another aspect of hysteresis in the PhoRB regulon. Phosphate starvation also leads to a global decline in transcription, counteracting the effects of positive autoregulation and resulting in a similar net pho response (homeostasis), regardless of exposure history.