Transcriptional Profile of Haemophilus influenzae : Effects of Iron and Heme | Zendy

Paul W. Whitby | Zendy; Timothy M. VanWagoner | Zendy; Thomas W. Seale | Zendy; Daniel J. Morton | Zendy; Terrence L. Stull | Zendy

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Transcriptional Profile of Haemophilus influenzae : Effects of Iron and Heme

Author(s) -

Paul W. Whitby,

Timothy M. VanWagoner,

Thomas W. Seale,

Daniel J. Morton,

Terrence L. Stull

Publication year - 2006

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.00417-06

Subject(s) - heme , haemophilus influenzae , biology , gene , microbiology and biotechnology , porphyrin , biochemistry , genetics , bacteria , enzyme

Haemophilus influenzae requires either heme or a porphyrin and iron source for growth. Microarray studies ofH. influenzae strain Rd KW20 identified 162 iron/heme-regulated genes, representing ∼10% of the genome, with ≥1.5-fold changes in transcription in response to iron/heme availability in vitro. Eighty genes were preferentially expressed under iron/heme restriction; 82 genes were preferentially expressed under iron/heme-replete conditions.

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