Loss of a Cardiolipin Synthase in Helicobacter pylori G27 Blocks Flagellum Assembly | Zendy

Joshua K. Chu | Zendy; Shiwei Zhu | Zendy; Carmen M. Herrera | Zendy; Jeremy C. Henderson | Zendy; Jun Liu | Zendy; M. Stephen Trent | Zendy; Timothy R. Hoover | Zendy

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Loss of a Cardiolipin Synthase in Helicobacter pylori G27 Blocks Flagellum Assembly

Author(s) -

Joshua K. Chu,

Shiwei Zhu,

Carmen M. Herrera,

Jeremy C. Henderson,

Jun Liu,

M. Stephen Trent,

Timothy R. Hoover

Publication year - 2019

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.00372-19

Subject(s) - flagellum , biology , mutant , cardiolipin , gene , genetics , microbiology and biotechnology , phospholipid , membrane

H. pylori colonizes the epithelial layer of the human stomach, where it can cause a variety of diseases, including chronic gastritis, peptic ulcer disease, and gastric cancer. To colonize the stomach,H. pylori must penetrate the viscous mucous layer lining the stomach, which it accomplishes using its flagella. The significance of our research is identifying factors that affect the biosynthesis and assembly of theH. pylori flagellum, which will contribute to our understanding of motility inH. pylori , as well as other bacterial pathogens that use their flagella for host colonization.

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