Open AccessGenomic Identification of a Novel Mutation in hfq That Provides Multiple Benefits in Evolving Glucose-Limited Populations of Escherichia coli
Author(s) -
Ram Maharjan,
Zhemin Zhou,
Yan Ren,
Yang Li,
Joël Gaffé,
Dominique Schneider,
Christopher Mckenzie,
Peter R. Reeves,
Thomas Ferenci,
Lei Wang
Publication year - 2010
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.00368-10
Subject(s) - biology , escherichia coli , genetics , mutation , genome , identification (biology) , mutation rate , mutation accumulation , gene , computational biology , botany
Beneficial mutations in diversifying glucose-limited Escherichia coli populations are mostly unidentified. The genome of an evolved isolate with multiple differences from that of the ancestor was fully assembled. Remarkably, a single mutation in hfq was responsible for the multiple benefits under glucose limitation through changes in at least five regulation targets.