Genetic, Biochemical, and Molecular Characterization of Methanosarcina barkeri Mutants Lacking Three Distinct Classes of Hydrogenase | Zendy

Thomas D. Mand | Zendy; Gargi Kulkarni | Zendy; William W. Metcalf | Zendy

Open Access

Genetic, Biochemical, and Molecular Characterization of Methanosarcina barkeri Mutants Lacking Three Distinct Classes of Hydrogenase

Author(s) -

Thomas D. Mand,

Gargi Kulkarni,

William W. Metcalf

Publication year - 2018

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.00342-18

Subject(s) - methanosarcina barkeri , biology , mutant , methanosarcina , hydrogenase , mutation , genetics , archaea , gene , biochemistry , methanomicrobiales , enzyme , bacteria , methanogenesis

Methanogenic archaea are key players in the global carbon cycle due to their ability to facilitate the remineralization of organic substrates in many anaerobic environments. The consequences of biological methanogenesis are far-reaching, with impacts on atmospheric methane and CO2 concentrations, agriculture, energy production, waste treatment, and human health. The data presented here clarify thein vivo function of hydrogenases during methanogenesis, which in turn deepens our understanding of this unique form of metabolism. This knowledge is critical for a variety of important issues ranging from atmospheric composition to human health.

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