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The mycobacterium-specific gene Rv2719c was found to be expressed primarily from a promoter that was clearly DNA damage inducible independently of RecA. Upstream of the transcriptional start site for this promoter, sequence motifs resembling those observed previously at the RecA-independent, DNA damage-induciblerecA promoter were identified, and the −10 motif was demonstrated by mutational analysis in transcriptional fusion constructs to be important for expression of Rv2719c.

The Mycobacterium-Specific Gene Rv2719c Is DNA Damage Inducible Independently of RecA