Open AccessProtein Domains and Residues Involved in the CheZ/CheA S Interaction
Author(s) -
Brian J. Cantwell,
Michael D. Manson
Publication year - 2009
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.00280-09
Subject(s) - biology , domain (mathematical analysis) , chemoreceptor , biochemistry , microbiology and biotechnology , receptor , mathematical analysis , mathematics
CheZ localizes to chemoreceptor patches by binding CheA-short (CheAS ). Residues 70 to 134 of CheZ, constituting the apical loops and part of the dimerization domain, suffice for localization. Replacements of Tyr-118, Ile-119, Leu-123, Arg-124, and Leu-126 of CheA interfere with localization. These residues are exposed in the ′P1 domain of CheAS .