A Two-Component System That Modulates Cyclic di-GMP Metabolism Promotes Legionella pneumophila Differentiation and Viability in Low-Nutrient Conditions | Zendy

Elisa Hughes | Zendy; Brenda Byrne | Zendy; Michele S. Swanson | Zendy

Open Access

A Two-Component System That Modulates Cyclic di-GMP Metabolism Promotes Legionella pneumophila Differentiation and Viability in Low-Nutrient Conditions

Author(s) -

Elisa Hughes,

Brenda Byrne,

Michele S. Swanson

Publication year - 2019

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.00253-19

Subject(s) - legionella pneumophila , biology , microbiology and biotechnology , legionella , metabolism , microbial metabolism , component (thermodynamics) , nutrient , bacteria , biochemistry , genetics , ecology , physics , thermodynamics

Although an intracellular pathogen,L. pneumophila has developed mechanisms to ensure long-term survival in low-nutrient aqueous conditions. Eradication ofL. pneumophila from contaminated water supplies has proven challenging, as outbreaks have been traced to previously remediated systems. Understanding the genetic determinants that supportL. pneumophila persistence in low-nutrient environments can inform design and assessment of remediation strategies. Here we characterize a genetic locus that encodes a two-component signaling system (lpg0278-lpg0277 ) and a putative regulator protein (lpg0279 ) that modulates the production of the messenger molecule cyclic di-GMP. We show that this locus promotes bothL. pneumophila cell differentiation and survival in nutrient-limiting conditions, thus advancing the understanding of the mechanisms that contribute toL. pneumophila environmental resilience.

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