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Although an intracellular pathogen,L. pneumophila has developed mechanisms to ensure long-term survival in low-nutrient aqueous conditions. Eradication ofL. pneumophila from contaminated water supplies has proven challenging, as outbreaks have been traced to previously remediated systems. Understanding the genetic determinants that supportL. pneumophila persistence in low-nutrient environments can inform design and assessment of remediation strategies. Here we characterize a genetic locus that encodes a two-component signaling system (lpg0278-lpg0277 ) and a putative regulator protein (lpg0279 ) that modulates the production of the messenger molecule cyclic di-GMP. We show that this locus promotes bothL. pneumophila cell differentiation and survival in nutrient-limiting conditions, thus advancing the understanding of the mechanisms that contribute toL. pneumophila environmental resilience.

journal of bacteriology

A Two-Component System That Modulates Cyclic di-GMP Metabolism Promotes Legionella pneumophila Differentiation and Viability in Low-Nutrient Conditions