Open AccessThe Conserved Sporulation Protein YneE Inhibits DNA Replication in Bacillus subtilis
Author(s) -
Lilah Rahn-Lee,
Boris Gorbatyuk,
Ole Skovgaard,
Richard Losick
Publication year - 2009
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.00216-09
Subject(s) - bacillus subtilis , biology , dna replication , gene , dna , chromosome , mutation , replication (statistics) , microbiology and biotechnology , spore , genetics , bacillaceae , bacteria , virology
Cells ofBacillus subtilis triggered to sporulate under conditions of rapid growth undergo a marked decrease in chromosome copy number, which was partially relieved by a mutation in the sporulation-induced geneyneE . Cells engineered to expressyneE during growth were impaired in viability and produced anucleate cells. We conclude that YneE is an inhibitor of DNA replication.
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