AcrS/EnvR Represses Expression of theacrABMultidrug Efflux Genes inEscherichia coli | Zendy

Hidetada Hirakawa | Zendy; Asuka Takumi-Kobayashi | Zendy; Ulrike Theisen | Zendy; Takahiro Hirata | Zendy; Kunihiko Nishino | Zendy; Akihito Yamaguchi | Zendy

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AcrS/EnvR Represses Expression of theacrABMultidrug Efflux Genes inEscherichia coli

Author(s) -

Hidetada Hirakawa,

Asuka Takumi-Kobayashi,

Ulrike Theisen,

Takahiro Hirata,

Kunihiko Nishino,

Akihito Yamaguchi

Publication year - 2008

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.00190-08

Subject(s) - efflux , biology , escherichia coli , gene , genetics , multiple drug resistance , multidrug resistance associated proteins , atp binding cassette transporter , drug resistance , transporter

The acrS regulatory gene is located upstream of the acrEF multidrug efflux system genes. However, the roles of AcrS in regulation of drug efflux pumps have not been clearly understood. Here we show that AcrS represses other multidrug efflux genes, acrAB, which encode a major efflux system in Escherichia coli.

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