Open AccessAcrS/EnvR Represses Expression of the acrAB Multidrug Efflux Genes in Escherichia coli
Author(s) -
Hidetada Hirakawa,
Asuka Takumi-Kobayashi,
Ulrike Theisen,
Takahiro Hirata,
Kunihiko Nishino,
Akihito Yamaguchi
Publication year - 2008
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.00190-08
Subject(s) - efflux , biology , escherichia coli , gene , genetics , multiple drug resistance , multidrug resistance associated proteins , atp binding cassette transporter , drug resistance , transporter
The acrS regulatory gene is located upstream of the acrEF multidrug efflux system genes. However, the roles of AcrS in regulation of drug efflux pumps have not been clearly understood. Here we show that AcrS represses other multidrug efflux genes, acrAB, which encode a major efflux system in Escherichia coli.