Evidence that AphB, Essential for the Virulence of Vibrio vulnificus , Is a Global Regulator
Author(s) -
Hee Gon Jeong,
Sang Ho Choi
Publication year - 2008
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.00058-08
Subject(s) - vibrio vulnificus , virulence , biology , regulator , microbiology and biotechnology , mutant , vibrionaceae , vibrio , motility , bacteria , genetics , gene
The Vibrio vulnificus aphB mutant was significantly less virulent than the wild type and was impaired in motility and adherence to host cells. Microarray analysis revealed that AphB of V. vulnificus (AphB(Vv)) influences the expression of over 10% of the V. vulnificus genome. The combined results indicated that AphB(Vv) is a global regulator contributing to the pathogenesis of V. vulnificus.
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