A Critical Region in the FlaA Flagellin Facilitates Filament Formation of the Vibrio cholerae Flagellum | Zendy

Mylea A. Echazarreta | Zendy; Johnathan L. Kepple | Zendy; Li-Hua Yen | Zendy; Yue Chen | Zendy; Karl E. Klose | Zendy

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A Critical Region in the FlaA Flagellin Facilitates Filament Formation of the Vibrio cholerae Flagellum

Author(s) -

Mylea A. Echazarreta,

Johnathan L. Kepple,

Li-Hua Yen,

Yue Chen,

Karl E. Klose

Publication year - 2018

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.00029-18

Subject(s) - flagellin , vibrio cholerae , flagellum , biology , protein filament , microbiology and biotechnology , cholera , motility , pilus , bacteria , genetics , virulence , gene

V. cholerae causes the severe diarrheal disease cholera. Its ability to swim is mediated by rotation of a polar flagellum, and this motility is integral to its ability to cause disease and persist in the environment. The current studies illuminate how one specific flagellin (FlaA) within a multiflagellin structure mediates formation of the flagellar filament, thus allowingV. cholerae to swim. This knowledge can lead to safer vaccines and potential therapeutics to inhibit cholera.

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