Repression of Intracellular Virulence Factors in Salmonella by the Hha and YdgT Nucleoid-Associated Proteins | Zendy

Umaporn Silphaduang | Zendy; Mariola Mascarenhas | Zendy; Mohamed A. Karmali | Zendy; Brian K. Coombes | Zendy

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Repression of Intracellular Virulence Factors in Salmonella by the Hha and YdgT Nucleoid-Associated Proteins

Author(s) -

Umaporn Silphaduang,

Mariola Mascarenhas,

Mohamed A. Karmali,

Brian K. Coombes

Publication year - 2007

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.00002-07

Subject(s) - biology , virulence , nucleoid , pathogenicity island , repressor , intracellular , salmonella enterica , gene , psychological repression , gene silencing , salmonella , microbiology and biotechnology , operon , genetics , bacteria , gene expression , escherichia coli

The Hha/YmoA family of nucleoid-associated proteins is involved in gene regulation in enterobacteria. In Salmonella enterica serovar Typhimurium, virulence genes required for intracellular growth are induced following host cell invasion but the proteins responsible for repressing these genes prior to host cell entry have not been fully identified. We demonstrate here that Hha is the major repressor responsible for silencing virulence genes carried in Salmonella pathogenicity island 2 prior to bacteria sensing an intracellular environmental cue.

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