Open AccessPlasmodium falciparum Parasites Expressing Pregnancy-Specific Variant Surface Antigens Adhere Strongly to the Choriocarcinoma Cell Line BeWo
Author(s) -
Rikke N. Haase,
Rosette Megnekou,
Maja Lundquist,
Michael F. Ofori,
Lars Hviid,
Trine Staalsøe
Publication year - 2006
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.74.5.3035-3038.2006
Subject(s) - biology , plasmodium falciparum , virology , antigen , protozoa , choriocarcinoma , cell culture , apicomplexa , plasmodium (life cycle) , immunology , microbiology and biotechnology , malaria , parasite hosting , genetics , world wide web , computer science
Placenta-sequesteringPlasmodium falciparum parasites causing pregnancy-associated malaria express pregnancy-specific variant surface antigens (VSAPAM ). We report here that VSAPAM -expressing patient isolates adhere strongly to the choriocarcinoma cell line BeWo and that the BeWo line can be used to efficiently select for VSAPAM expression in vitro.