Open AccessCleavage of the N-Linked Oligosaccharide from the Surfaces of Chlamydia Species Affects Infectivity in the Mouse Model of Lung Infection
Author(s) -
Lee Ann Campbell,
Amy Lee,
ChoChou Kuo
Publication year - 2006
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.74.5.3027-3029.2006
Subject(s) - infectivity , biology , glycan , oligosaccharide , microbiology and biotechnology , mannose , in vitro , in vivo , chlamydia , cleavage (geology) , organism , virology , immunology , glycoprotein , biochemistry , virus , genetics , paleontology , fracture (geology)
Previous studies determined that theChlamydia glycan contains a high-mannose oligosaccharide, which is involved in attachment and infectivity of the organism, and that removal of the glycan decreases infectivity in vitro. The present study demonstrates that treatment of the organism withN -glycanase decreases or ablates infectivity in vivo.