Open AccessBgp, a Secreted Glycosaminoglycan-Binding Protein of Borrelia burgdorferi Strain N40, Displays Nucleosidase Activity and Is Not Essential for Infection of Immunodeficient Mice
Author(s) -
Nikhat Parveen,
Ken Cornell,
James L. Bono,
Christen Chamberland,
Patricia A. Rosa,
John M. Leong
Publication year - 2006
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.74.5.3016-3020.2006
Subject(s) - biology , borrelia burgdorferi , glycosaminoglycan , strain (injury) , microbiology and biotechnology , lyme disease , virology , immunology , anatomy , antibody
Bgp, one of the surface-localized glycosaminoglycan-binding proteins of the Lyme disease spirochete,Borrelia burgdorferi , exhibited nucleosidase activity. Infection of SCID mice withB. burgdorferi strain N40 mutants harboring a targeted insertion inbgp and apparently retaining all endogenous plasmids revealed that Bgp is not essential for colonization of immunocompromised mice.