Open AccessPosttranslational Regulation of Mycobacterium tuberculosis Extracytoplasmic-Function Sigma Factor σ L and Roles in Virulence and in Global Regulation of Gene Expression
Author(s) -
Elisa Dainese,
Sébastien Rodrigue,
Giovanni Delogu,
Roberta Provvedi,
Liette Laflamme,
Ryszard Brzeziński,
Giovanni Fadda,
Issar Smith,
Luc Gaudreau,
Giorgio Palù,
Riccardo Manganelli
Publication year - 2006
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.74.4.2457-2461.2006
Subject(s) - biology , sigma factor , virulence , mycobacterium tuberculosis , virulence factor , gene expression , function (biology) , regulation of gene expression , microbiology and biotechnology , gene , bacterial protein , genetics , tuberculosis , promoter , medicine , pathology
In this report, we demonstrate that SigL is posttranslationally regulated by a specific anti-sigma factor, RslA, and contributes to the expression of at least 28 genes. Several of these genes could mediate important cell envelope-related processes. Importantly, a sigL-rslA mutant strain was significantly attenuated in a mouse model of infection.