Open AccessSelective Binding of Borrelia burgdorferi OspE Paralogs to Factor H and Serum Proteins from Diverse Animals: Possible Expansion of the Role of OspE in Lyme Disease Pathogenesis
Author(s) -
Kelley M. Hovis,
Emily Tran,
Christina M. Sundy,
Eric L. Buckles,
John V. McDowell,
Richard T. Marconi
Publication year - 2006
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.74.3.1967-1972.2006
Subject(s) - borrelia burgdorferi , biology , lyme disease , pathogenesis , borrelia , spirochaetaceae , microbiology and biotechnology , immunology , virology , genetics , antibody
The binding ofBorrelia burgdorferi OspE, OspF, and family 163 (Elp) proteins to factor H/factor H-like protein 1 (FHL-1) and other serum proteins from different animals was assessed. OspE paralogs bound factor H and unidentified serum proteins from a subset of animals, while OspF and Elp proteins did not. These data advance our understanding of factor H binding, the host range of the Lyme spirochetes, and the expanding role of OspE in pathogenesis.