Open AccessSalmonella enterica Serovar Typhimurium ompS1 and ompS2 Mutants Are Attenuated for Virulence in Mice
Author(s) -
Olivia Rodríguez-Morales,
Marcos FernándezMora,
Ismael Hernández-Lucas,
Arturo Pérez Vázquez,
José L. Puente,
Edmundo Calva
Publication year - 2006
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.74.2.1398-1402.2006
Subject(s) - virulence , salmonella enterica , biology , microbiology and biotechnology , salmonella , mutant , serotype , enterobacteriaceae , gene , attenuated vaccine , virology , mutation , bacteria , genetics , escherichia coli
Salmonella enterica serovar Typhimurium mutants with mutations in theompS1 andompS2 genes, which code for quiescent porins, were nevertheless highly attenuated for virulence in a mouse model, indicating a role in pathogenesis. Similarly, a strain with a mutation in the gene coding for LeuO, a positive regulator ofompS2 , was also attenuated.