Open AccessKatA, the Major Catalase, Is Critical for Osmoprotection and Virulence in Pseudomonas aeruginosa PA14
Author(s) -
Jisun Lee,
Yong Heo,
Chang Kyu Lee,
YouHee Cho
Publication year - 2005
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.73.7.4399-4403.2005
Subject(s) - virulence , biology , pseudomonas aeruginosa , catalase , microbiology and biotechnology , pseudomonas , pseudomonadaceae , pseudomonadales , drosophila melanogaster , osmotic shock , bacteria , oxidative stress , genetics , biochemistry , gene
We demonstrate that among the three monofunctional catalases of Pseudomonas aeruginosa PA14, KatA and, to a lesser extent, KatB, but not KatE, are required for resistance to peroxide and osmotic stresses. KatA is crucial for adaptation to H2O2 stress and full virulence in both Drosophila melanogaster and mice. This dismantling of catalase roles represents a specialized catalytic system primarily involving KatA in responses to adverse environmental conditions.