Open AccessEnteropathogenic Escherichia coli Type III Effectors EspG and EspG2 Disrupt the Microtubule Network of Intestinal Epithelial Cells
Author(s) -
Robert K. Shaw,
Katherine Smollett,
Jennifer Cleary,
Junkal Garmendia,
Ania Straatman-Iwanowska,
Gad Frankel,
Stuart Knutton
Publication year - 2005
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.73.7.4385-4390.2005
Subject(s) - microtubule , biology , enteropathogenic escherichia coli , effector , escherichia coli , microbiology and biotechnology , cytoskeleton , tubulin , cell , genetics , gene
Enteropathogenic Escherichia coli infection of intestinal epithelial cells leads to localized depletion of the microtubule cytoskeleton, an effect that is dependent on delivery of type III translocated effector proteins EspG and Orf3 (designated EspG2) to the site of depletion. Microtubule depletion involved disruption rather than displacement of microtubules.