Open AccessProfile of Gene Expression in a Murine Model of Allergic Bronchopulmonary Aspergillosis
Author(s) -
Viswanath P. Kurup,
Raghavan Raju,
Pachiappan Manickam
Publication year - 2005
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.73.7.4381-4384.2005
Subject(s) - allergic bronchopulmonary aspergillosis , biology , gene , chemokine , immunology , aspergillosis , immune system , aspergillus fumigatus , gene expression , signal transduction , chemokine receptor , cytokine , ccr2 , microbiology and biotechnology , transmembrane protein , aspergillus , receptor , immunoglobulin e , genetics , antibody
Allergic bronchopulmonary aspergillosis (ABPA) results from the interactions of the Aspergillus allergens and immune system of the patients. We studied the gene expression profile in a mouse model of ABPA. Of the 12,000 genes studied, 1,300 genes showed enhanced expression and represent chemokine, cytokine, growth factor, signal transduction, and transmembrane receptor genes as well as genes related to arginine metabolism.