Open AccessPlasmodium falciparum Merozoite Surface Protein 6 Displays Multiple Targets for Naturally Occurring Antibodies That Mediate Monocyte-Dependent Parasite Killing
Author(s) -
Subhash Singh,
Soe Soé,
Christian Roussilhon,
Giampietro Corradin,
Pierre Druilhe
Publication year - 2005
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.73.2.1235-1238.2005
Subject(s) - biology , plasmodium falciparum , epitope , parasite hosting , antibody , merozoite surface protein , antigen , virology , monocyte , microbiology and biotechnology , protozoa , apicomplexa , surface protein , malaria , malaria vaccine , genetics , immunology , world wide web , computer science
Plasmodium falciparum MSP6 is a merozoite surface antigen that shows organization and sequence homologies similar to those of MSP3. Within its C-terminus conserved region, it presents some epitopes that are cross-reactive with MSP3 and others that are not, both being targets of naturally occurring antibodies that block the P. falciparum erythrocytic cycle in cooperation with monocytes.