Open AccessDefective Phagocytosis in Anaplasma phagocytophilum - Infected Neutrophils
Author(s) -
Justin Garyu,
Kwang Shik Choi,
Dennis J. Grab,
J. Stephen Dumler
Publication year - 2005
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.73.2.1187-1190.2005
Subject(s) - anaplasma phagocytophilum , phagocytosis , biology , microbiology and biotechnology , candida albicans , internalization , immunology , neutrophile , anaplasma , granulocyte , virology , inflammation , cell , antibody , genetics , tick , borrelia burgdorferi
Anaplasma phagocytophilum infection induces functional neutrophil changes. Using both Candida albicans and fluorescent-aggregate phagocytosis assays, we examined whether neutrophil and dimethyl sulfoxide-differentiated HL-60 cell infection impairs internalization. A. phagocytophilum infection significantly decreased phagocytosis compared to that of controls (P < 0.05). This further impairment of neutrophil function may promote opportunistic infections and exacerbate disease.