Open AccessIntrapulmonary, Adenovirus-Mediated Overexpression of KARAP/DAP12 Enhances Fungal Clearance during Invasive Aspergillosis
Author(s) -
Kristin J. Carpenter,
Karen Buckland,
Zhou Xing,
Cory M. Hogaboam
Publication year - 2005
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.73.12.8402-8406.2005
Subject(s) - biology , aspergillosis , adenoviridae , signal transducing adaptor protein , peripheral blood mononuclear cell , vector (molecular biology) , mycosis , aspergillus fumigatus , viral vector , immunology , virology , microbiology and biotechnology , genetic enhancement , in vitro , signal transduction , recombinant dna , gene , biochemistry
Herein, we report that the intrapulmonary delivery of an adenovirus vector expressing KARAP/DAP12, an adaptor protein expressed in granulocytes and mononuclear cells, enhanced fungal clearance during experimental invasive pulmonary aspergillosis in neutropenic mice.