Open AccessInduction of SAP7 Correlates with Virulence in an Intravenous Infection Model of Candidiasis but Not in a Vaginal Infection Model in Mice
Author(s) -
Brad N. Taylor,
H Hannemann,
Miriam Sehnal,
Antje Biesemeier,
Anja Schweizer,
Martin Röllinghoff,
Klaus Schröppel
Publication year - 2005
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.73.10.7061-7063.2005
Subject(s) - virulence , candida albicans , biology , microbiology and biotechnology , vagina , corpus albicans , ratón , vaginitis , phenotype , vaginal disease , immunology , gene , genetics
SAP7 ofCandida albicans is induced after vaginal infection of mice. Conversely, virulence during vaginal infection was not affected in a Δsap7/ Δsap7 mutant strain. Only a partial virulence phenotype was detectable after intravenous injection. In conclusion,SAP7 expression does not correlate withC. albicans virulence in mice.