Open AccessDifferential Monocyte Activation Underlies Strain-SpecificMycobacterium tuberculosisPathogenesis
Author(s) -
Claudia Manca,
Michael B. Reed,
Sherry Freeman,
Barun Mathema,
Barry N. Kreiswirth,
Clifton E. Barry,
Gilla Kaplan
Publication year - 2004
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.72.9.5511-5514.2004
Subject(s) - mycobacterium tuberculosis , biology , phagocyte , chemokine , microbiology and biotechnology , immunity , monocyte , tuberculosis , immunology , cellular immunity , cytokine , pathogenesis , virology , immune system , medicine , pathology
In vitro infection of monocytes with Mycobacterium tuberculosis HN878 and related W/Beijing isolates preferentially induced interleukin-4 (IL-4) and IL-13, which characterize Th2 polarized immunity. In contrast, CDC1551 induced more IL-12 and other molecules associated with phagocyte activation and Th1 protective immunity. The differential cytokine-chemokine response was mediated by extracted lipids, suggesting that these molecules regulate host responses to infection.