Open AccessRole of Flagellum and Motility in Pathogenesis of Vibrio vulnificus
Author(s) -
Jong-Ho Lee,
Jong Bok Rho,
Kyung-Je Park,
Chang Beom Kim,
Yang-Soo Han,
Sang Ho Choi,
KyuHo Lee,
SoonJung Park
Publication year - 2004
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.72.8.4905-4910.2004
Subject(s) - flagellum , vibrio vulnificus , biology , microbiology and biotechnology , mutant , vibrio , motility , vibrionaceae , biofilm , pathogenesis , virulence , pathogenicity , bacteria , genetics , gene , immunology
To assess the role of the flagellum which was detected by immunoscreening of surface proteins of Vibrio vulnificus, an flgE-deleted mutant was constructed and tested for its pathogenicity. The ability of this nonmotile mutant to adhere to INT-407 cells and its role in biofilm were decreased, as was its lethality to mice.