Open AccessPseudomonas aeruginosa Pyocyanin Is Critical for Lung Infection in Mice
Author(s) -
Gee W. Lau,
Huimin Ran,
Fanrong Kong,
Daniel J. Hassett,
Dmitri V. Mavrodi
Publication year - 2004
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.72.7.4275-4278.2004
Subject(s) - pyocyanin , pseudomonas aeruginosa , biology , cystic fibrosis , lung , microbiology and biotechnology , respiratory tract , immunology , biofilm , respiratory system , bacteria , medicine , anatomy , quorum sensing , genetics
Pseudomonas aeruginosa secretes copious amounts of the redox-active phenazine, pyocyanin (PCN), during cystic fibrosis lung infection. PCN has been shown to interfere with a variety of cellular processes in cultured lung epithelial cells. Here, by using two respiratory tract models of infection, we demonstrate that PCN mediates tissue damage and necrosis during lung infection.