Open AccessAnaplasma phagocytophilumInfection Induces Protracted Neutrophil Degranulation
Author(s) -
Kwang Shik Choi,
Dennis J. Grab,
J. Stephen Dumler
Publication year - 2004
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.72.6.3680-3683.2004
Subject(s) - anaplasma phagocytophilum , degranulation , biology , anaplasma , immunology , anaplasmosis , microbiology and biotechnology , inflammation , neutrophile , virology , antibody , tick , borrelia burgdorferi , biochemistry , receptor
Anaplasma phagocytophilum-infected neutrophil degranulation could exacerbate inflammation. Thus, the degranulation of infected neutrophils was assayed. Infected neutrophils expressed CD11b and CD66b, and supernatants of infected neutrophils showed more proMMP-9 and MMP-9 activity than controls and continued to do so for > or =18 h. Degranulation-related inflammatory tissue injury may account for some clinical manifestations in human granulocytic anaplasmosis.