Open AccessIncreased Susceptibility of β7-Integrin-Deficient Neonatal Mice in the Early Stage of Cryptosporidium parvum Infection
Author(s) -
Roselyne Mancassola,
Sonia LacroixLamandé,
M. Barrier,
Muriel Naciri,
Henri Salmon,
Fabrice Laurent
Publication year - 2004
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.72.6.3634-3637.2004
Subject(s) - cryptosporidium parvum , biology , cryptosporidium , neonatal infection , microbiology and biotechnology , virology , immunology , feces , pregnancy , genetics
Numerous inflammatory cells are recruited in response to Cryptosporidium parvum infection. These cells include interferon gamma-producing T lymphocytes, which are of major importance for the resolution of infection. Here, we show that beta7 integrin is not essential for the control of infection in mice but that beta7-deficient neonatal mice are more susceptible during the early stages of infection.