Open AccessTwoSalmonellaOmpC Kb-Restricted Epitopes for CD8+-T-Cell Recognition
Author(s) -
Alberto Diaz-Quiñonez,
Natalia MartínOrozco,
Armando Isibasí,
Vianney Ortiz-Navarrete
Publication year - 2004
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.72.5.3059-3062.2004
Subject(s) - porin , biology , epitope , cytotoxic t cell , salmonella , major histocompatibility complex , cd8 , microbiology and biotechnology , bacterial outer membrane , t cell , antigen , virology , bacteria , escherichia coli , immune system , immunology , biochemistry , genetics , gene , in vitro
We report the identification of two peptides from Salmonella OmpC porin that can bind to major histocompatibility complex class I K(b) molecules and are targets of cytotoxic T lymphocytes from Salmonella-infected mice. These peptides are conserved in gram-negative bacterial porins and are the first Salmonella porin-specific epitopes described for possible CD8(+)-T-cell elimination of infected cells.