Open AccessCerebral Edema and Cerebral Hemorrhages in Interleukin-10-Deficient Mice Infected with Plasmodium chabaudi
Author(s) -
Latifu A. Sanni,
William Jarra,
Ching Li,
Jean Langhorne
Publication year - 2004
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.72.5.3054-3058.2004
Subject(s) - plasmodium chabaudi , cerebral malaria , cerebral edema , proinflammatory cytokine , edema , plasmodium berghei , biology , tumor necrosis factor alpha , immunology , interleukin , interleukin 6 , cerebral cortex , pathology , medicine , parasitemia , inflammation , cytokine , anesthesia , malaria , endocrinology , plasmodium falciparum
During a Plasmodium chabaudi infection in interleukin-10 (IL-10) knockout mice, there is greater parasite sequestration, more severe cerebral edema, and a high frequency of cerebral hemorrhage compared with infection of C57BL/6 mice. Anti-tumor necrosis factor alpha treatment ameliorated both cerebral edema and hemorrhages, suggesting that proinflammatory responses contributed to cerebral complications in infected IL-10(-/-) mice.